Laboklin test svar

Report No.: 2102-W-10222 Haarby Dyreklinik Date of arrival: 12.02.2021 Postvaenget 2 Date of report: 17.02.2021 5683 Haarby Testing started: 12.02.2021 Dänemark Testing completed: 17.02.2021

Species: Dog Breed: Border Collie Gender: Male Name: Astra Expert Stud book No.: DK 11875/2017 Chip No.: 956000004395425 Date of birth / Age: 05.05.2015

Type of sample: EDTA-Blood Date sample was taken: 04.02.2021 Owner / Animal-ID: Jensen, Rita IT No. / Report-ID: --- Raine Syndrome - PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype-allele.

It does not carry the c

Raine Syndrome - PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for Raine Syndrome in the FAM20C-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds:

Border Collie

Imerslund-Gräsbeck-Syndrome (IGS) - PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for IGS in the CUBN-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds:

Border Collie

Trapped Neutrophil Syndrome (TNS) - PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for TNS in the VPS13B-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Border Collie

Neuronal Ceroid Lipofuszinosis (NCL) -PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for NCL in the CL5-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Border Collie, Australian Cattle Dog

Glaucoma and Goniodysgenesis (GG) - PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype allele. It does not carry the causative mutation for glaucoma in the OLFML3 gene. Trait of inheritance: autosomal recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Border Collie

Sensory Neuropathy (SN) - PCR Result: Genotype N/SN Interpretation: The examined animal is heterozygous for the causative mutation for SN in the FAM134B-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Border Collie

MDR1 genetic test - PCR Result: Genotype N/N (+/+) Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for MDR in the ABCB1-gene. Trait of inheritance: autosomal-recessive The DNA-test is run according to the publication of Mealey et al. (2001) "Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene." and detects the mutation MDR1 nt230 (del4). MDR1 genetic test carried out according to DIN EN ISO/IEC 17025 in our partnerlaboratory. Liability for specification of samples (e.g. name, identity of animal) lies by the sender.

Collie Eye Anomaly (CEA) - PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for CEA in the NHEJ1-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Australian Kelpie and Shepherd, Bearded Collie, Border Collie, Boykin Spaniel, Hokkaido, Lancashire Heeler, Longhaired Wippet, Nova Scotia Duck Tolling Retriever, Rough/Smooth Collie, Shetland Sheepdogs, Silken Windhound The current result is only valid for the sample submitted to our laboratory. The sender is responsible for the correct information regarding the sample material.The laboratory can not be made liable. Furthermore, any obligation for compensation is limited to the value of the tests performed. There is a possibility that other mutations may have caused the disease/phenotype. The analysis was performed according to the latest knowledge and technology. The laboratory is accredited for the performed tests according to DIN EN ISO/IEC 17025:2018. (except partner lab tests). Please note