Laboklin Silas

Border collie pakken

Ford Martin alias Silas

Report No.: 2009-W-50929 Haarby Dyreklinik Date of arrival: 25.09.2020 Postvaenget 2 Date of report: 01.10.2020 5683 Haarby Testing started: 25.09.2020 Dänemark Testing completed: 01.10.2020 Species: Dog Breed: Border Collie Gender: Male Name: Aston Martin of Dynamic Pleasure Stud book No.: DK 07029/2020 Chip No.: 953000010433411 Date of birth / Age: 20.08.2019 Type of sample: EDTA-Blood Date sample was taken: 22.09.2020 Treating veterinarian: Naja Buhl Helms (447) Owner / Animal-ID: Jensen, Rita IT No. / Report-ID: ---

Raine Syndrome - PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for Raine Syndrome in the FAM20C-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Border Collie

Imerslund-Gräsbeck-Syndrome (IGS) - PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for IGS in the CUBN-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Border Collie

Trapped Neutrophil Syndrome (TNS) - PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for TNS in the VPS13B-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Border Collie

Neuronal Ceroid Lipofuszinosis (NCL) -PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for NCL in the CL5-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Border Collie, Australian Cattle Dog

Glaucoma and Goniodysgenesis (GG) - PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype allele. It does not carry the causative mutation for glaucoma in the OLFML3 gene. Trait of inheritance: autosomal recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Border Collie

Sensory Neuropathy (SN) - PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for SN in the FAM134B-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Border Collie

MDR1 genetic test - PCR Result: Genotype N/N (+/+) Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for MDR in the ABCB1-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Australian Shepherd, Border Collie, Elo, German Shepherd, Longhaired Whippet, McNab, Old English Sheepdog, Rough/Smooth Collie, Shetland Sheepdog, Silken Windhound, Wäller, White Shepherd

Please note: in individual cases, heterozygous dogs can show clinical signs! The DNA-test is run according to the publication of Mealey et al. (2001) "Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene." and detects the mutation MDR1 nt230 (del4). MDR1 genetic test carried out according to DIN EN ISO/IEC 17025 in our partnerlaboratory. Liability for specification of samples (e.g. name, identity of animal) lies by the sender.

Collie Eye Anomaly (CEA) - PCR Result: Genotype N/N Interpretation: The examined animal is homozygous for the wildtype-allele. It does not carry the causative mutation for CEA in the NHEJ1-gene. Trait of inheritance: autosomal-recessive Scientific studies found correlation between the mutation and symptoms of the disease in the following breeds: Australian Kelpie and Shepherd, Bearded Collie, Border Collie, Boykin Spaniel, Hokkaido, Lancashire Heeler, Longhaired Wippet, Nova Scotia Duck Tolling Retriever, Rough/Smooth Collie, Shetland Sheepdogs, Silken Windhound The current result is only valid for the sample submitted to our laboratory. The sender is responsible for the correct information regarding the sample material.The laboratory can not be made liable. Furthermore, any obligation for compensation is limited to the value of the tests performed. There is a possibility that other mutations may have caused the disease/phenotype. The analysis was performed according to the latest knowledge and technology. The laboratory is accredited for the performed tests according to DIN EN ISO/IEC 17025:2005. (except partner lab tests).

These results are based on the sample material submitted to our laboratory. This was suitable if not stated otherwise. The submitter is responsible for the accuracy of the information regarding the sample. This report can only be transmitted in toto and unchanged. Doing otherwise requires written permission from Laboklin GmbH & Co. KG. Fr. MSc Michelle Meißler Abt. Molekularbiologie